Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.56 |
| ▸ | WHR1 | P49842 | 2/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.52 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.52 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.50 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.45 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1942476 | 0.88 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DWHR1 | |
| SCHEMBL1941945 | 0.88 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DWHR1 | |
| SCHEMBL22144635 | 0.88 | WHR1 (0.68) | PDE4APDE4BPDE4CPDE4DWHR1 | |
| SCHEMBL1942369 | 0.86 | PDE4B (0.52) | PDE4APDE4BPDE4CPDE4DWHR1 | |
| SCHEMBL1942139 | 0.84 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DWHR1 | |
| SCHEMBL1940360 | 0.83 | WHR1 (0.55) | PDE4APDE4DWHR1ADORA2AMAPT | |
| SCHEMBL16502036 | 0.83 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4DWHR1 | |
| SCHEMBL1943249 | 0.83 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DWHR1 | |
| SCHEMBL6774540 | 0.83 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DWHR1 | |
| SCHEMBL1941528 | 0.83 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DWHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6800644-B2 | PHOSPHODIESTERASE-4 INHIBITOR, AMINOQUINOLINE OR AMINOISOQUINOLINE DERIVATIVES | EISAI CO., LTD. (JP) | 2004-10-05 | — | — | US | disclosed |
| US-20020055516-A1 | Nitrogen-containing heterocyclic compounds and medicaments containing the compounds | EISAI CO., LTD. | 2002-05-09 | — | — | US | disclosed |
| US-6352989-B1 | ENZYME INHIBITORS FOR PHOSPHODIESTERASE | EISAI CO., LTD. (JP) | 2002-03-05 | — | — | US | disclosed |
| EP-1052254-A1 | NITROGENOUS HETEROCYCLIC DERIVATIVES AND MEDICINE THEREOF | Eisai Co., Ltd. (JP) | 2000-11-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020055516-A1 | Nitrogen-containing heterocyclic compounds and medicaments containing the compounds | PDE4A, PDE4B, PDE5A | PDE4A 1/4885PDE4B 2/4885PDE4C 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.