Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 13/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20673453 | 1.00 | MC4R (0.44) | MC4RSMN1; SMN2KDM4EL3MBTL1FFAR4 | |
| SCHEMBL26330641 | 0.88 | L3MBTL1 (0.48) | MC4RL3MBTL1FFAR4MEN1TSHR | |
| SCHEMBL19403753 | 0.85 | MC4R (0.45) | MC4RL3MBTL1FFAR4MEN1TSHR | |
| SCHEMBL20673523 | 0.83 | MC4R (0.43) | MC4RL3MBTL1FFAR4MEN1TSHR | |
| SCHEMBL23549955 | 0.81 | USP2 (0.55) | MC4RSMN1; SMN2L3MBTL1MEN1KMT2A | |
| SCHEMBL19403828 | 0.81 | USP2 (0.55) | MC4RSMN1; SMN2L3MBTL1MEN1KMT2A | |
| SCHEMBL20673452 | 0.80 | MC4R (0.59) | MC4R | |
| SCHEMBL23549989 | 0.79 | MC4R (0.44) | MC4RFFAR4MEN1TSHRKMT2A | |
| SCHEMBL20673520 | 0.79 | MC4R (0.45) | MC4RL3MBTL1FFAR4MEN1TSHR | |
| SCHEMBL19403746 | 0.78 | L3MBTL1 (0.48) | MC4RL3MBTL1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017165822-A1 | SMALL MOLECULE INHIBITOR OF THE NUCLEAR TRANSLOCATION OF ANDROGEN RECEPTOR FOR THE TREATMENT OF CASTRATION-RESISTANT PROSTATE CANCER | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2017-09-28 | — | — | WO | disclosed |