Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD1 | O95696 | 14/20 | 0.77 |
| ▸ | BRPF1 | P55201 | 14/20 | 0.77 |
| ▸ | TAF1 | P21675 | 13/20 | 0.77 |
| ▸ | BRD4 | O60885 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | TAF1L | Q8IZX4 | 1/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.46 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.46 |
| ▸ | BRPF3 | Q9ULD4 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19404521 | 0.87 | BRD1 (1.00) | BRD1BRPF1TAF1BRD4MEN1 | |
| SCHEMBL19404857 | 0.85 | BRD1 (0.77) | BRD1BRPF1TAF1BRD4MEN1 | |
| SCHEMBL19405003 | 0.81 | BRD1 (0.74) | BRD1BRPF1TAF1BRD4LMNA | |
| SCHEMBL19405037 | 0.79 | BRD1 (1.00) | BRD1BRPF1TAF1BRD4MEN1 | |
| SCHEMBL18648444 | 0.78 | MEN1 (0.64) | BRD1BRPF1TAF1MEN1KMT2A | |
| SCHEMBL19405059 | 0.78 | BRD1 (0.70) | BRD1BRPF1TAF1BRD4MEN1 | |
| SCHEMBL19405032 | 0.78 | BRD1 (1.00) | BRD1BRPF1TAF1BRD4MEN1 | |
| SCHEMBL19404467 | 0.78 | BRD1 (1.00) | BRD1BRPF1TAF1BRD4MEN1 | |
| SCHEMBL19404616 | 0.77 | BRD1 (0.66) | BRD1BRPF1TAF1BRD4MEN1 | |
| SCHEMBL19404532 | 0.77 | BRD1 (0.66) | BRD1BRPF1TAF1BRD4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017162661-A1 | 1H-BENZO[DE]ISOQUINOLINE-1,3(2H)-DIONES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-09-28 | — | — | WO | disclosed |