Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 7/20 | 0.59 |
| ▸ | EGFR | P00533 | 13/20 | 0.58 |
| ▸ | SRC | P12931 | 8/20 | 0.58 |
| ▸ | ABL1 | P00519 | 6/20 | 0.58 |
| ▸ | ABL2 | P42684 | 5/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.57 |
| ▸ | ERBB3 | P21860 | 7/20 | 0.57 |
| ▸ | ERBB4 | Q15303 | 7/20 | 0.57 |
| ▸ | TEK | Q02763 | 7/20 | 0.57 |
| ▸ | KDR | P35968 | 4/20 | 0.55 |
| ▸ | LCK | P06239 | 4/20 | 0.52 |
| ▸ | CSF1R | P07333 | 2/20 | 0.52 |
| ▸ | IGF1R | P08069 | 2/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.52 |
| ▸ | FLT1 | P17948 | 2/20 | 0.52 |
| ▸ | FLT3 | P36888 | 2/20 | 0.52 |
| ▸ | MST1R | Q04912 | 2/20 | 0.52 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.52 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.52 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27620914 | 0.87 | EGFR (0.66) | RETEGFRSRCABL1ABL2 | |
| SCHEMBL27639717 | 0.83 | EGFR (0.62) | RETEGFRSRCABL1ABL2 | |
| SCHEMBL1941336 | 0.83 | EGFR (0.66) | RETEGFRSRCABL1ABL2 | |
| SCHEMBL1941717 | 0.82 | EGFR (0.66) | RETEGFRSRCABL1ABL2 | |
| SCHEMBL1940517 | 0.82 | RET (0.60) | RETEGFRSRCABL1ABL2 | |
| SCHEMBL5122419 | 0.82 | RET (0.61) | RETEGFRSRCABL1ABL2 | |
| SCHEMBL27620922 | 0.81 | EGFR (0.58) | RETEGFRSRCABL1ABL2 | |
| SCHEMBL1941497 | 0.81 | EGFR (0.68) | RETEGFRSRCABL1ABL2 | |
| SCHEMBL1941272 | 0.81 | EGFR (0.65) | RETEGFRSRCABL1ABL2 | |
| SCHEMBL5351174 | 0.81 | EGFR (0.67) | RETEGFRSRCABL1ABL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578751-B1 | PYRROLOPYRIMIDINE DERIVATIVES | PFIZER PROD INC (US) | 2011-06-15 | — | — | EP | disclosed |
| US-7271262-B2 | Pyrrolopyrimidine derivatives | PFIZER INC (US) | 2007-09-18 | — | — | US | disclosed |
| CN-1726218-A | Pyrrolopyrimidine derivatives | PFIZER PROD INC (US) | 2006-01-25 | — | — | CN | disclosed |
| US-20050037999-A1 | Pyrrolopyrimidine derivatives | PFIZER INC | 2005-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050037999-A1 | Pyrrolopyrimidine derivatives | CCNA1, CCNT1, TP53 | RET 672/4885EGFR 2758/4885SRC 2491/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.