Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.62 |
| ▸ | SRC | P12931 | 8/20 | 0.62 |
| ▸ | ABL1 | P00519 | 8/20 | 0.62 |
| ▸ | ABL2 | P42684 | 8/20 | 0.62 |
| ▸ | TEK | Q02763 | 8/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.56 |
| ▸ | ERBB3 | P21860 | 6/20 | 0.56 |
| ▸ | ERBB4 | Q15303 | 6/20 | 0.56 |
| ▸ | KDR | P35968 | 4/20 | 0.54 |
| ▸ | LCK | P06239 | 4/20 | 0.54 |
| ▸ | RET | P07949 | 2/20 | 0.54 |
| ▸ | LYN | P07948 | 2/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.54 |
| ▸ | INSR | P06213 | 1/20 | 0.54 |
| ▸ | NPM1 | P06748 | 1/20 | 0.54 |
| ▸ | CSF1R | P07333 | 1/20 | 0.54 |
| ▸ | IGF1R | P08069 | 1/20 | 0.54 |
| ▸ | MET | P08581 | 1/20 | 0.54 |
| ▸ | ROS1 | P08922 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1940945 | 0.83 | RET (0.59) | EGFRSRCABL1ABL2TEK | |
| SCHEMBL1942471 | 0.83 | EGFR (0.64) | EGFRSRCABL1ABL2TEK | |
| SCHEMBL27620914 | 0.82 | EGFR (0.66) | EGFRSRCABL1ABL2TEK | |
| SCHEMBL1941272 | 0.82 | EGFR (0.65) | EGFRSRCABL1ABL2TEK | |
| SCHEMBL27620922 | 0.80 | EGFR (0.58) | EGFRSRCABL1ABL2TEK | |
| SCHEMBL1940517 | 0.79 | RET (0.60) | EGFRSRCABL1ABL2TEK | |
| SCHEMBL1941717 | 0.79 | EGFR (0.66) | EGFRSRCABL1ABL2TEK | |
| SCHEMBL1942885 | 0.77 | EGFR (0.58) | EGFRSRCABL1ABL2TEK | |
| SCHEMBL5936173 | 0.77 | SRC (0.97) | EGFRSRCABL1ABL2TEK | |
| SCHEMBL5122419 | 0.77 | RET (0.61) | EGFRSRCABL1ABL2TEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1726218-A | Pyrrolopyrimidine derivatives | PFIZER PROD INC (US) | 2006-01-25 | — | — | CN | disclosed |