Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.53 |
| ▸ | ERBB3 | P21860 | 7/20 | 0.53 |
| ▸ | ERBB4 | Q15303 | 7/20 | 0.53 |
| ▸ | TEK | Q02763 | 6/20 | 0.53 |
| ▸ | ITGA1 | P56199 | 2/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | EIF2AK3 | Q9NZJ5 | 2/20 | 0.40 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 2/20 | 0.38 |
| ▸ | CHKA | P35790 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | WDR5 | P61964 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1941177 | 0.92 | EGFR (0.54) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1941198 | 0.88 | ITGA1 (0.52) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1941033 | 0.85 | EGFR (0.70) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1941423 | 0.85 | EGFR (0.73) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1940584 | 0.85 | EGFR (0.47) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1940713 | 0.84 | EGFR (0.74) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1940475 | 0.83 | PDGFRB (0.70) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1940619 | 0.82 | PDGFRB (0.60) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1941037 | 0.81 | ITGA1 (0.52) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1940974 | 0.80 | EGFR (0.54) | EGFRERBB2ERBB3ERBB4TEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578751-B1 | PYRROLOPYRIMIDINE DERIVATIVES | PFIZER PROD INC (US) | 2011-06-15 | — | — | EP | disclosed |