Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.55 |
| ▸ | ERBB3 | P21860 | 8/20 | 0.55 |
| ▸ | ERBB4 | Q15303 | 8/20 | 0.55 |
| ▸ | TEK | Q02763 | 7/20 | 0.55 |
| ▸ | RET | P07949 | 8/20 | 0.51 |
| ▸ | KDR | P35968 | 3/20 | 0.50 |
| ▸ | SRC | P12931 | 5/20 | 0.46 |
| ▸ | ABL1 | P00519 | 5/20 | 0.46 |
| ▸ | ABL2 | P42684 | 4/20 | 0.46 |
| ▸ | LCK | P06239 | 3/20 | 0.45 |
| ▸ | IGF1R | P08069 | 3/20 | 0.44 |
| ▸ | CSF1R | P07333 | 2/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.43 |
| ▸ | FLT1 | P17948 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | MST1R | Q04912 | 2/20 | 0.43 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.43 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1939527 | 0.88 | EGFR (0.62) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1941583 | 0.86 | EGFR (0.70) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1940714 | 0.85 | EGFR (0.54) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1941717 | 0.85 | EGFR (0.66) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1940517 | 0.85 | RET (0.60) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1939918 | 0.82 | EGFR (0.58) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1942885 | 0.81 | EGFR (0.58) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1941219 | 0.81 | EGFR (0.75) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1940945 | 0.80 | RET (0.59) | EGFRERBB2ERBB3ERBB4TEK | |
| SCHEMBL1942902 | 0.78 | EGFR (0.73) | EGFRERBB2ERBB3ERBB4TEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578751-B1 | PYRROLOPYRIMIDINE DERIVATIVES | PFIZER PROD INC (US) | 2011-06-15 | — | — | EP | disclosed |
| CN-1726218-A | Pyrrolopyrimidine derivatives | PFIZER PROD INC (US) | 2006-01-25 | — | — | CN | disclosed |