Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA7 | P43166 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | BCR | P11274 | 1/20 | 0.33 |
| ▸ | MLYCD | O95822 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18771941 | 0.92 | HPGD (0.41) | TLR8HPGDMAPK1MAOASMN1; SMN2 | |
| SCHEMBL18771971 | 0.91 | HPGD (0.40) | TLR8HPGDMAPK1MAOASMN1; SMN2 | |
| SCHEMBL18771727 | 0.84 | TLR8 (0.42) | TLR8HPGDMAPK1SMN1; SMN2TSHR | |
| SCHEMBL18772018 | 0.84 | TLR8 (0.58) | TLR8 | |
| SCHEMBL18771966 | 0.84 | TLR8 (0.36) | TLR8HPGDMAPK1MAOASMN1; SMN2 | |
| SCHEMBL18771745 | 0.84 | TLR8 (0.36) | TLR8HPGDMAPK1MAOASMN1; SMN2 | |
| SCHEMBL18771953 | 0.84 | TLR8 (0.50) | TLR8HPGDMAPK1SMN1; SMN2KMT2A | |
| SCHEMBL18771820 | 0.83 | TLR8 (0.57) | TLR8 | |
| SCHEMBL18771994 | 0.83 | TLR8 (0.42) | TLR8HPGDMAPK1SMN1; SMN2KMT2A | |
| SCHEMBL18772123 | 0.83 | TLR8 (0.39) | TLR8HPGDMAPK1MAOASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3225623-A1 | SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS | Ventirx Pharmaceuticals, Inc. (US) | 2017-10-04 | — | — | EP | disclosed |