Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 6/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19265449 | 0.92 | TLR8 (0.41) | TLR8HPGDL3MBTL1KDM4ETLR7 | |
| SCHEMBL18771971 | 0.89 | HPGD (0.40) | TLR8HPGDALDH1A1NPC1RAB9A | |
| SCHEMBL18771941 | 0.88 | HPGD (0.41) | TLR8HPGDALDH1A1SMN1; SMN2HRH3 | |
| SCHEMBL18771820 | 0.88 | TLR8 (0.57) | TLR8TLR7 | |
| SCHEMBL18772018 | 0.87 | TLR8 (0.58) | TLR8TLR7 | |
| SCHEMBL18771953 | 0.87 | TLR8 (0.50) | TLR8HPGDTLR7ALDH1A1SMN1; SMN2 | |
| SCHEMBL19265459 | 0.86 | HPGD (0.40) | TLR8HPGDL3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL18771933 | 0.85 | TLR8 (0.34) | TLR8HPGDKDM4ETLR7ALDH1A1 | |
| SCHEMBL18771940 | 0.85 | TLR8 (0.48) | TLR8HPGDTLR7HRH3MAPK1 | |
| SCHEMBL18772002 | 0.84 | HPGD (0.37) | TLR8HPGDTLR7ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3159337-A2 | SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS | Ventirx Pharmaceuticals, Inc. (US) | 2017-04-26 | — | — | EP | disclosed |