Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 9/20 | 0.52 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CA7 | P43166 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18771724 | 0.91 | TLR8 (0.56) | TLR8TLR7HPGDMAPK1CSF1R | |
| SCHEMBL19416362 | 0.90 | TLR8 (0.57) | TLR8TLR7HPGDMAPK1CSF1R | |
| SCHEMBL18772009 | 0.83 | TLR8 (0.78) | TLR8TLR7 | |
| SCHEMBL19265594 | 0.82 | TLR8 (0.46) | TLR8TLR7HPGDMAPK1CSF1R | |
| SCHEMBL18772027 | 0.82 | TLR8 (0.77) | TLR8TLR7 | |
| SCHEMBL18772102 | 0.82 | TLR8 (0.67) | TLR8TLR7 | |
| SCHEMBL18772198 | 0.82 | TLR8 (0.62) | TLR8TLR7 | |
| SCHEMBL18772061 | 0.79 | TLR8 (0.55) | TLR8TLR7 | |
| SCHEMBL18772181 | 0.79 | TLR8 (0.71) | TLR8TLR7 | |
| SCHEMBL18772033 | 0.79 | TLR8 (0.62) | TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3225623-A1 | SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS | Ventirx Pharmaceuticals, Inc. (US) | 2017-10-04 | — | — | EP | disclosed |