Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 5/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16000804 | 0.86 | MAPK14 (0.40) | NOTUMALOX12KMT2AMAPTALDH1A1 | |
| SCHEMBL19416842 | 0.84 | NOTUM (0.51) | NOTUMTRPV1ALOX12KMT2AMAPT | |
| SCHEMBL15992489 | 0.77 | POLB (0.38) | NOTUMKMT2AMAPTALDH1A1TP53 | |
| SCHEMBL16000815 | 0.72 | NOTUM (0.46) | NOTUMALOX12KMT2AMAPTALDH1A1 | |
| SCHEMBL8899318 | 0.70 | NOTUM (0.68) | NOTUMALOX12KMT2AMAPTALDH1A1 | |
| SCHEMBL97043 | 0.70 | NOTUM (0.68) | NOTUMALOX12KMT2AMAPTALDH1A1 | |
| SCHEMBL21792052 | 0.70 | NOTUM (0.73) | NOTUMTRPV1ALOX12KMT2AALDH1A1 | |
| SCHEMBL19416838 | 0.69 | NOTUM (0.42) | NOTUMTRPV1KMT2AMAPTALDH1A1 | |
| SCHEMBL24922903 | 0.68 | NOTUM (0.61) | NOTUMALDH1A1LMNAPOLBNPC1 | |
| SCHEMBL335739 | 0.68 | RECQL (0.39) | POLBNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2709609-B1 | HETEROCYCLIC COMPOUNDS | SHIONOGI & CO (JP) | 2017-10-04 | — | — | EP | disclosed |