Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAT | P00750 | 2/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | TLR2 | O60603 | 1/20 | 0.32 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.32 |
| ▸ | PTGES | O14684 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15717839 | 0.83 | PSEN1 (0.38) | NTRK1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL15739571 | 0.82 | SCN5A (0.36) | PLATNTRK1PSEN1PSEN2APH1B | |
| SCHEMBL15717686 | 0.78 | POLB (0.39) | CYP19A1NTRK1PSEN1PSEN2APH1B | |
| SCHEMBL15717641 | 0.75 | POLB (0.35) | NTRK1GPR119SCN5A | |
| SCHEMBL15739671 | 0.74 | NTRK1 (0.36) | PLATNTRK1GPR119KCNH2SCN5A | |
| SCHEMBL15717522 | 0.74 | POLB (0.36) | NTRK1 | |
| SCHEMBL15717850 | 0.74 | PPARD (0.40) | NTRK1SCN5A | |
| SCHEMBL15762381 | 0.74 | MAP4K4 (0.39) | NTRK1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL15717584 | 0.73 | DHFR (0.41) | NTRK1GPR119 | |
| SCHEMBL15717888 | 0.73 | MAP4K4 (0.48) | NTRK1PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925757-B1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES | NOVARTIS AG (CH) | 2017-10-04 | — | — | EP | disclosed |