Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | PIM1 | P11309 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15717839 | 0.80 | PSEN1 (0.38) | NTRK1SCN5AJAK2CYP11B1CYP11B2 | |
| SCHEMBL15717888 | 0.78 | MAP4K4 (0.48) | NTRK1MEN1KMT2AMAP4K4CAMKK1 | |
| SCHEMBL15739671 | 0.76 | NTRK1 (0.36) | NTRK1SCN5AJAK2CYP11B1CYP11B2 | |
| SCHEMBL15717880 | 0.76 | KIF11 (0.46) | NTRK1SCN5AJAK2CYP11B2KDM4E | |
| SCHEMBL15739571 | 0.76 | SCN5A (0.36) | NTRK1SCN5AJAK2CYP11B1CYP11B2 | |
| SCHEMBL15762381 | 0.76 | MAP4K4 (0.39) | NTRK1SCN5APIM1MAP4K4CAMKK1 | |
| SCHEMBL15717968 | 0.75 | NTRK1 (0.43) | NTRK1MAP4K4CAMKK1CAMKK2KIF11 | |
| SCHEMBL15717465 | 0.74 | MAPK14 (0.42) | NTRK1SCN5ALMNA | |
| SCHEMBL15717686 | 0.73 | POLB (0.39) | NTRK1CYP11B1CYP11B2 | |
| SCHEMBL15739562 | 0.73 | P2RY14 (0.44) | NTRK1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925757-B1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES | NOVARTIS AG (CH) | 2017-10-04 | — | — | EP | disclosed |