Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 11/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | KCNJ6 | P48051 | 2/20 | 0.37 |
| ▸ | KCNJ5 | P48544 | 2/20 | 0.37 |
| ▸ | KCNJ3 | P48549 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1939148 | 0.80 | SLC22A12 (0.49) | SLC22A12CHRNA7ADORA1ADORA3ADORA2A | |
| SCHEMBL1940540 | 0.79 | GRM4 (0.45) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL2306802 | 0.77 | SLC22A12 (0.50) | SLC22A12CHRNA7ADORA1ADORA3ADORA2A | |
| SCHEMBL1942089 | 0.74 | CNR2 (0.45) | SLC22A12ADORA1ADORA3ADORA2ACNR2 | |
| SCHEMBL2305448 | 0.74 | SLC22A12 (0.55) | SLC22A12ADORA1ADORA3ADORA2AKCNJ6 | |
| SCHEMBL1941016 | 0.73 | CNR1 (0.46) | SLC22A12ADORA1ADORA3ADORA2ACNR2 | |
| SCHEMBL27983382 | 0.71 | CNR1 (0.52) | SLC22A12ALDH1A1SMN1; SMN2CNR2 | |
| SCHEMBL1940935 | 0.69 | CA12 (0.44) | SLC22A12ADORA1ADORA3ADORA2ACNR2 | |
| SCHEMBL1940064 | 0.68 | SLC22A12 (0.46) | SLC22A12ADORA1ADORA3ADORA2A | |
| SCHEMBL5188426 | 0.68 | GRM4 (0.39) | SLC22A12CHRNA7ADORA1ADORA3ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8173679-B2 | Indazoles, benzisoxazoles and benzisothiazoles and their use as estrogenic agents | LABORATOIRE THERMAMEX (MC) | 2012-05-08 | — | — | US | disclosed |
| US-20110237624-A1 | INDAZOLES, BENZISOXAZOLES AND BENZISOTHIAZOLES AND THEIR USE AS ESTROGENIC AGENTS | LABORATOIRE THERAMEX (MC) | 2011-09-29 | — | — | US | disclosed |
| US-7977364-B2 | Indazoles, benzisoxazoles and benzisothiazoles and their use as estrogenic agents | LABORATOIRE THERMAMEX (MC) | 2011-07-12 | — | — | US | disclosed |
| EP-1812404-B1 | INDAZOLES, BENZISOXAZOLES AND BENZISOTHIAZOLES AND THEIR USE AS ESTROGENIC AGENTS | THERAMEX (MC) | 2011-06-15 | — | — | EP | disclosed |
| US-20090023779-A1 | Indazoles, benzisoxazoles and benzisothiazoles and their use as estrogenic agents | LABORATOIRE THERAMEX (FR) | 2009-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023779-A1 | Indazoles, benzisoxazoles and benzisothiazoles and their use as estrogenic agents | ESR1, ESR2, GPER1 | SLC22A12 3816/4885CHRNA7 706/4885ADORA1 724/4885 |
| US-20110237624-A1 | INDAZOLES, BENZISOXAZOLES AND BENZISOTHIAZOLES AND THEIR USE AS ESTROGENIC AGENTS | ESR1, ESR2, GPER1 | SLC22A12 3816/4885CHRNA7 706/4885ADORA1 724/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.