Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 5/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | TRIM24 | O15164 | 2/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.38 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.37 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1940226 | 0.84 | TRIM24 (0.36) | GRM4CYP1A2TRIM24SCN9ASCN5A | |
| SCHEMBL1941836 | 0.79 | SLC22A12 (0.46) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL1941997 | 0.77 | ESR1 (0.49) | GRM4CYP1A2DDB1CRBNHTR3A | |
| SCHEMBL2197603 | 0.77 | PTGS2 (0.44) | GRM4CYP1A2DDB1CRBN | |
| SCHEMBL1940542 | 0.74 | STS (0.48) | — | |
| SCHEMBL1941097 | 0.73 | SGK1 (0.48) | GRM4CYP1A2 | |
| SCHEMBL23535645 | 0.68 | CNR1 (0.45) | GRM4CYP1A2DDB1CRBN | |
| SCHEMBL30159707 | 0.68 | CNR1 (0.45) | GRM4CYP1A2DDB1CRBN | |
| SCHEMBL23535801 | 0.68 | CYP1A2 (0.43) | GRM4CYP1A2HTR3ALMNAMAPT | |
| SCHEMBL30159624 | 0.68 | CYP1A2 (0.43) | GRM4CYP1A2HTR3ALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812404-B1 | INDAZOLES, BENZISOXAZOLES AND BENZISOTHIAZOLES AND THEIR USE AS ESTROGENIC AGENTS | THERAMEX (MC) | 2011-06-15 | — | — | EP | disclosed |