Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.61 |
| ▸ | F13A1 | P00488 | 1/20 | 0.60 |
| ▸ | TGM2 | P21980 | 1/20 | 0.60 |
| ▸ | MKNK2 | Q9HBH9 | 6/20 | 0.54 |
| ▸ | FLT3 | P36888 | 6/20 | 0.44 |
| ▸ | KIT | P10721 | 6/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 6/20 | 0.44 |
| ▸ | KDR | P35968 | 6/20 | 0.44 |
| ▸ | FLT4 | P35916 | 4/20 | 0.44 |
| ▸ | FLT1 | P17948 | 3/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.43 |
| ▸ | CDK2 | P24941 | 4/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.43 |
| ▸ | PLK4 | O00444 | 2/20 | 0.43 |
| ▸ | CDK1 | P06493 | 2/20 | 0.43 |
| ▸ | AXL | P30530 | 2/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10150507 | 0.88 | F13A1 (0.77) | HSP90AB1F13A1TGM2MKNK2FLT3 | |
| SCHEMBL10150038 | 0.88 | F13A1 (0.77) | HSP90AB1F13A1TGM2MKNK2FLT3 | |
| SCHEMBL10150437 | 0.88 | F13A1 (0.77) | HSP90AB1F13A1TGM2MKNK2FLT3 | |
| SCHEMBL14293730 | 0.87 | HSP90AB1 (0.62) | HSP90AB1F13A1TGM2MKNK2FLT3 | |
| SCHEMBL19418404 | 0.83 | HSP90AB1 (0.63) | HSP90AB1F13A1TGM2MKNK2FLT3 | |
| SCHEMBL10150144 | 0.80 | KDR (0.67) | HSP90AB1F13A1TGM2MKNK2FLT3 | |
| SCHEMBL10150367 | 0.77 | HSP90AB1 (0.56) | HSP90AB1F13A1TGM2MKNK2FLT3 | |
| SCHEMBL10150430 | 0.77 | HSP90AB1 (0.56) | HSP90AB1F13A1TGM2MKNK2FLT3 | |
| SCHEMBL10150199 | 0.77 | HSP90AB1 (0.56) | HSP90AB1F13A1TGM2MKNK2FLT3 | |
| SCHEMBL4510614 | 0.77 | MKNK2 (0.63) | HSP90AB1F13A1TGM2MKNK2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2136799-B1 | MACROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF KINASES AND HSP90 | UNIV STRASBOURG (FR) | 2017-10-04 | — | — | EP | disclosed |