Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPID | Q08752 | 15/20 | 0.47 |
| ▸ | PPIB | P23284 | 4/20 | 0.40 |
| ▸ | PPIG | Q13427 | 5/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19429765 | 0.90 | PPID (0.50) | PPIDPPIBPPIGADAM17TDP1 | |
| SCHEMBL19423570 | 0.83 | PPID (0.68) | PPIDPPIBPPIG | |
| SCHEMBL19423575 | 0.83 | PPID (0.45) | PPIDPPIBPPIGKMT2A | |
| SCHEMBL19423718 | 0.83 | PPID (0.45) | PPIDPPIBPPIGKMT2A | |
| SCHEMBL19429945 | 0.80 | PPID (0.47) | PPIDPPIBPPIGALDH1A1KMT2A | |
| SCHEMBL19410099 | 0.79 | PPID (0.71) | PPIDPPIBPPIG | |
| SCHEMBL19421462 | 0.79 | PPID (0.71) | PPIDPPIBPPIG | |
| SCHEMBL19429766 | 0.79 | PPID (0.71) | PPIDPPIBPPIG | |
| SCHEMBL12643852 | 0.76 | PPID (0.78) | PPIDPPIBPPIGADAM17ALDH1A1 | |
| SCHEMBL19423760 | 0.76 | PPID (0.49) | PPIDPPIBPPIGADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017173048-A1 | COMPOUNDS FOR THE INHIBITION OF CYCLOPHILINS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2017-10-05 | — | — | WO | disclosed |