Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 13/20 | 0.76 |
| ▸ | BCL2 | P10415 | 8/20 | 0.76 |
| ▸ | BAD | Q92934 | 2/20 | 0.71 |
| ▸ | MDM4 | O15151 | 1/20 | 0.71 |
| ▸ | BCL2L11 | O43521 | 1/20 | 0.71 |
| ▸ | TP53 | P04637 | 1/20 | 0.71 |
| ▸ | BID | P55957 | 1/20 | 0.71 |
| ▸ | BAX | Q07812 | 1/20 | 0.71 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.71 |
| ▸ | ASPH | Q12797 | 1/20 | 0.71 |
| ▸ | BECN1 | Q14457 | 1/20 | 0.71 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.71 |
| ▸ | BCL2L2 | Q92843 | 1/20 | 0.71 |
| ▸ | BBC3 | Q9BXH1 | 1/20 | 0.71 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.67 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.67 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.67 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.67 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.67 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19424287 | 0.99 | BCL2L1 (0.76) | BCL2L1BCL2BADMDM4BCL2L11 | |
| SCHEMBL19424189 | 0.98 | BCL2L1 (0.76) | BCL2L1BCL2BADMDM4BCL2L11 | |
| SCHEMBL19424383 | 0.96 | BCL2L1 (0.76) | BCL2L1BCL2BADMDM4BCL2L11 | |
| SCHEMBL19424186 | 0.95 | BCL2L1 (0.83) | BCL2L1BCL2BADMDM4BCL2L11 | |
| SCHEMBL19424284 | 0.94 | BCL2L1 (0.74) | BCL2L1BCL2BADMDM4BCL2L11 | |
| SCHEMBL19424455 | 0.94 | BCL2L1 (0.74) | BCL2L1BCL2BADMDM4BCL2L11 | |
| SCHEMBL19424293 | 0.94 | BCL2L1 (0.74) | BCL2L1BCL2BADMDM4BCL2L11 | |
| SCHEMBL19424288 | 0.94 | BCL2L1 (0.74) | BCL2L1BCL2BADMDM4BCL2L11 | |
| SCHEMBL19424289 | 0.94 | BCL2L1 (0.73) | BCL2L1BCL2BADMDM4BCL2L11 | |
| SCHEMBL19424195 | 0.93 | BCL2L1 (0.77) | BCL2L1BCL2BADMDM4BCL2L11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10195213-B2 | Chemical entities that kill senescent cells for use in treating age-related disease | UNITY BIOTECHNOLOGY, INC. (US) | 2019-02-05 | — | — | US | disclosed |
| US-20170281649-A1 | COMPOUNDS AND THERAPEUTIC USES | UNITY BIOTECHNOLOGY, INC. | 2017-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170281649-A1 | COMPOUNDS AND THERAPEUTIC USES | TP53, NQO1, SHMT2 | BCL2L1 953/4885BCL2 520/4885BAD 421/4885 |
| US-10195213-B2 | Chemical entities that kill senescent cells for use in treating age-related disease | TP53, CDKN1A, GLA | BCL2L1 464/4885BCL2 132/4885BAD 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.