Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | BCL2L1 | Q07817 | 6/20 | 0.55 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.52 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.48 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | BCL2 | P10415 | 4/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.47 |
| ▸ | BCL2A1 | Q16548 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | IDH1 | O75874 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3473744 | 0.96 | BCL2L1 (0.60) | MEN1HTTRAB9AKMT2ABCL2L1 | |
| SCHEMBL3474740 | 0.80 | BCL2L1 (0.67) | BCL2L1BCL2MCL1BCL2A1 | |
| SCHEMBL19420192 | 0.78 | BCL2L1 (0.64) | BCL2L1BCL2MCL1BCL2A1 | |
| SCHEMBL10192109 | 0.73 | KMT2A (0.74) | MEN1HTTRAB9AKMT2AKCNK3 | |
| SCHEMBL12764063 | 0.72 | MEN1 (1.00) | MEN1HTTRAB9AKMT2AKCNK3 | |
| SCHEMBL15847043 | 0.72 | KCNK3 (0.92) | MEN1HTTRAB9AKMT2AKCNK3 | |
| SCHEMBL3472615 | 0.72 | BCL2L1 (0.67) | BCL2L1KDM4EBCL2MCL1BCL2A1 | |
| SCHEMBL14394718 | 0.72 | P2RX1 (0.78) | MEN1HTTRAB9AKMT2AKCNK3 | |
| SCHEMBL352825 | 0.72 | BCL2L1 (1.00) | BCL2L1BCL2MCL1BCL2A1 | |
| SCHEMBL9080921 | 0.72 | MEN1 (0.66) | MEN1HTTRAB9AKMT2AKCNK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10195213-B2 | Chemical entities that kill senescent cells for use in treating age-related disease | UNITY BIOTECHNOLOGY, INC. (US) | 2019-02-05 | — | — | US | disclosed |
| US-20170281649-A1 | COMPOUNDS AND THERAPEUTIC USES | UNITY BIOTECHNOLOGY, INC. | 2017-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170281649-A1 | COMPOUNDS AND THERAPEUTIC USES | TP53, NQO1, SHMT2 | MEN1 3416/4885HTT 356/4885RAB9A 1412/4885 |
| US-10195213-B2 | Chemical entities that kill senescent cells for use in treating age-related disease | TP53, CDKN1A, GLA | MEN1 2434/4885HTT 368/4885RAB9A 831/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.