Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.83 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.62 |
| ▸ | BCL2L11 | O43521 | 1/20 | 0.55 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.55 |
| ▸ | PDE1A | P54750 | 2/20 | 0.51 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.51 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.51 |
| ▸ | PTGER4 | P35408 | 5/20 | 0.42 |
| ▸ | PTGER3 | P43115 | 5/20 | 0.42 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.42 |
| ▸ | PTGER2 | P43116 | 4/20 | 0.42 |
| ▸ | PLA2G1B | P04054 | 3/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19420098 | 0.92 | BCL2L1 (0.75) | BCL2L1MCL1TP53MDM2BCL2L11 | |
| SCHEMBL254749 | 0.91 | BCL2L1 (1.00) | BCL2L1MCL1TP53MDM2BCL2L11 | |
| SCHEMBL5559504 | 0.86 | BCL2L1 (0.74) | BCL2L1MCL1TP53MDM2BCL2L11 | |
| SCHEMBL17805815 | 0.82 | BCL2L1 (0.84) | BCL2L1MCL1TP53MDM2BCL2L11 | |
| SCHEMBL4652392 | 0.79 | BCL2L1 (0.79) | BCL2L1MCL1TP53MDM2BCL2L11 | |
| SCHEMBL4652386 | 0.79 | BCL2L1 (0.79) | BCL2L1MCL1TP53MDM2BCL2L11 | |
| SCHEMBL4651385 | 0.78 | BCL2L1 (0.98) | BCL2L1MCL1TP53MDM2BCL2L11 | |
| SCHEMBL14066614 | 0.77 | BCL2L1 (0.67) | BCL2L1MCL1TP53MDM2BCL2L11 | |
| SCHEMBL14347691 | 0.77 | BCL2L1 (0.71) | BCL2L1MCL1TP53MDM2BCL2L11 | |
| SCHEMBL4651590 | 0.77 | TP53 (1.00) | BCL2L1MCL1TP53MDM2BCL2L11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10195213-B2 | Chemical entities that kill senescent cells for use in treating age-related disease | UNITY BIOTECHNOLOGY, INC. (US) | 2019-02-05 | — | — | US | disclosed |
| US-20170281649-A1 | COMPOUNDS AND THERAPEUTIC USES | UNITY BIOTECHNOLOGY, INC. | 2017-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170281649-A1 | COMPOUNDS AND THERAPEUTIC USES | TP53, NQO1, SHMT2 | BCL2L1 953/4885MCL1 137/4885TP53 1/4885 |
| US-10195213-B2 | Chemical entities that kill senescent cells for use in treating age-related disease | TP53, CDKN1A, GLA | BCL2L1 464/4885MCL1 8/4885TP53 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.