Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPID | Q08752 | 17/20 | 0.51 |
| ▸ | PPIG | Q13427 | 4/20 | 0.44 |
| ▸ | PPIB | P23284 | 2/20 | 0.44 |
| ▸ | PPIA | P62937 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19426921 | 0.87 | PPID (0.54) | PPIDPPIGPPIBPPIA | |
| SCHEMBL19423572 | 0.85 | PPID (0.70) | PPIDPPIGPPIBPPIA | |
| SCHEMBL19430051 | 0.82 | PPID (0.56) | PPIDPPIGPPIBPPIA | |
| SCHEMBL19423566 | 0.82 | PPID (0.70) | PPIDPPIGPPIBPPIA | |
| SCHEMBL19423764 | 0.82 | PPID (0.70) | PPIDPPIGPPIBPPIA | |
| SCHEMBL19409787 | 0.82 | PPID (0.75) | PPIDPPIGPPIBPPIA | |
| SCHEMBL19426894 | 0.82 | PPID (0.75) | PPIDPPIGPPIBPPIA | |
| SCHEMBL19429941 | 0.81 | PPID (0.71) | PPIDPPIGPPIBPPIA | |
| SCHEMBL19423571 | 0.76 | PPID (0.68) | PPIDPPIGPPIBPPIA | |
| SCHEMBL19426954 | 0.75 | KMT2A (0.47) | PPIDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170283426-A1 | COMPOUNDS FOR THE INHIBITION OF CYCLOPHILINS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2017-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170283426-A1 | COMPOUNDS FOR THE INHIBITION OF CYCLOPHILINS AND USES THEREOF | PPIG, PPIH, FKBP2 | PPID 17/4885PPIG 1/4885PPIB 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.