Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ACVRL1 | P37023 | 4/20 | 0.36 |
| ▸ | DOT1L | Q8TEK3 | 3/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.32 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.32 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.32 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.32 |
| ▸ | TNK2 | Q07912 | 4/20 | 0.32 |
| ▸ | POLRMT | O00411 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20960065 | 0.93 | MAP4K4 (0.37) | CSNK2A2CSNK2A1MAP4K4KDM4EHTT | |
| SCHEMBL31391115 | 0.92 | MAP4K4 (0.43) | MAP4K4KDM4EHTTACVRL1DOT1L | |
| SCHEMBL16011257 | 0.85 | ACVRL1 (0.46) | CSNK2A2CSNK2A1MAP4K4ACVRL1DOT1L | |
| SCHEMBL16011256 | 0.85 | ACVRL1 (0.46) | CSNK2A2CSNK2A1MAP4K4ACVRL1DOT1L | |
| SCHEMBL19377633 | 0.84 | AXL (0.39) | MAP4K4ACVRL1DOT1L | |
| SCHEMBL19377694 | 0.82 | PIK3CD (0.42) | CSNK2A2CSNK2A1MAP4K4 | |
| SCHEMBL22627061 | 0.82 | ACVRL1 (0.51) | MAP4K4ACVRL1ALDH1A1 | |
| SCHEMBL19377637 | 0.82 | EGLN2 (0.40) | MAP4K4KDM4EHTTACVRL1DOT1L | |
| SCHEMBL14488031 | 0.81 | MAP4K4 (0.37) | CSNK2A2CSNK2A1MAP4K4ACVRL1DOT1L | |
| SCHEMBL21120475 | 0.81 | DOT1L (0.35) | MAP4K4ACVRL1DOT1LTNK2POLRMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017172596-A1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORPORATION (US) | 2017-10-05 | — | — | WO | disclosed |