Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPID | Q08752 | 3/20 | 0.43 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 7/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.34 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19423585 | 0.87 | CYP4F2 (0.43) | PPIDCYP4F2CYP4A11TRPV1RIPK1 | |
| SCHEMBL19429945 | 0.86 | PPID (0.47) | PPIDPOLBLTA4HHPGD | |
| SCHEMBL19423571 | 0.82 | PPID (0.68) | PPID | |
| SCHEMBL19423587 | 0.77 | PPID (0.48) | PPIDCYP4F2CYP4A11POLBL3MBTL1 | |
| SCHEMBL19421503 | 0.74 | PPID (0.68) | PPIDCYP4F2CYP4A11POLBL3MBTL1 | |
| SCHEMBL19429951 | 0.74 | PPID (0.68) | PPIDCYP4F2CYP4A11POLBL3MBTL1 | |
| SCHEMBL19410030 | 0.74 | PPID (0.68) | PPIDCYP4F2CYP4A11POLBL3MBTL1 | |
| SCHEMBL19423718 | 0.73 | PPID (0.45) | PPIDPOLB | |
| SCHEMBL19423582 | 0.72 | PPID (0.53) | PPIDPOLBLTA4HHPGD | |
| SCHEMBL19430092 | 0.72 | PPID (0.43) | PPIDTRPV1POLBLTA4HHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170283425-A1 | COMPOUNDS FOR THE INHIBITION OF CYCLOPHILINS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2017-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170283425-A1 | COMPOUNDS FOR THE INHIBITION OF CYCLOPHILINS AND USES THEREOF | PPIG, PPIH, FKBP2 | PPID 17/4885CYP4F2 683/4885CYP4A11 1023/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.