⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL74789 | 0.83 | — | — | |
| SCHEMBL8671614 | 0.75 | QPCT (0.38) | — | |
| SCHEMBL158171 | 0.74 | PARP1 (0.58) | — | |
| SCHEMBL2496364 | 0.72 | ALDH1A1 (0.32) | — | |
| SCHEMBL5756878 | 0.70 | QPCT (0.40) | — | |
| Benzimidazole SCHEMBL1293052 | 0.70 | SMN1; SMN2 (0.48) | — | |
| Benzimidazole SCHEMBL2971795 | 0.70 | SMN1; SMN2 (0.48) | — | |
| Benzimidazole SCHEMBL7773385 | 0.68 | KDM4E (0.50) | — | |
| Benzimidazole SCHEMBL10432218 | 0.68 | KDM4E (0.50) | — | |
| Benzimidazole SCHEMBL4441683 | 0.68 | SMN1; SMN2 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 9068 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6410577-B1 | — | — | None | — | — | US | claimed |
| EP-4392032-A1 | MODULATORS OF THE BETA-3 ADRENERGIC RECEPTOR FOR THE TREATMENT OR PREVENTION OF RENAL CYSTIC DISEASE AND CARDIORENAL SYNDROME | Arena Pharmaceuticals, Inc. (US) | 2024-07-03 | — | — | EP | claimed |
| US-12011444-B2 | N-substituted indole derivatives as PGE2 receptor modulators | IDORSIA PHARMACEUTICALS LTD (CH) | 2024-06-18 | — | — | US | claimed |
| CN-118201911-A | Compounds and their use as GPR183 inhibitors | 南京艾美斐生物医药科技有限公司 | 2024-06-14 | — | — | CN | claimed |
| US-11987588-B2 | Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of heart failure and disorders related thereto | ARENA PHARMACEUTICALS, INC. (US) | 2024-05-21 | — | — | US | claimed |
| US-20240124474-A1 | HER2 MUTATION INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2024-04-18 | — | — | US | claimed |
| US-20240116910-A1 | Heterocycles as WIP1 Inhibitors | PMV PHARMACEUTICALS, INC. | 2024-04-11 | — | — | US | claimed |
| CN-117836296-A | Pyrazolopyridone compounds | 百济神州有限公司 | 2024-04-05 | — | — | CN | claimed |
| WO-2024036183-A1 | ANTAGONISTS OF 5-HYDROXYTRYPTAMINE RECEPTOR SUBTYPE 2B | VANDERBILT UNIVERSITY (US) | 2024-02-15 | — | — | WO | claimed |
| US-11897880-B2 | 7,8-dihydrobenzo[e]pyrido[3,4-c]azocine-2,5(3H,6H)-dione derivatives useful as a factor XIa inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2024-02-13 | — | — | US | claimed |
| US-5091533-A | Treating allergies, cardiovascular disorders, inflammation | MERCK FROSST CANADA, INC. (CA) | 1992-02-25 | — | — | US | claimed |
| EP-0445781-A1 | 3-Arylcarbonyl-1-aminoalkyl-1H-indole containing antiglaucoma compositions | STERLING WINTHROP INC. (US) | 1991-09-11 | — | — | EP | claimed |
| EP-0238507-A4 | POTENT, SELECTIVE OPIOID RECEPTOR AGONISTS AND ANTAGONISTS. | RZESZOTARSKI JANUSZ WACLAW (US) | 1990-02-26 | — | — | EP | claimed |
| US-4889860-A | ANALGESICS, ANTISHOCK AGENTS, DIETETICS, ANTIHALLUCINOGENS; SIDE EFFECT REDUCTION | NOVA PHARMACEUTICAL CORPORATION (US) | 1989-12-26 | — | — | US | claimed |
| US-4760069-A | A selective opioid receptor agonist or antagonist | NOVA PHARMACEUTICAL CORPORATION (US) | 1988-07-26 | — | — | US | claimed |
| US-4734515-A | 1:2 metal complexes of 2-nitroso-acetoacetic acid and benzoylacetic acid arylamides | SANDOZ LTD. (CH) | 1988-03-29 | — | — | US | claimed |
| EP-0238507-A1 | POTENT, SELECTIVE OPIOID RECEPTOR AGONISTS AND ANTAGONISTS | RZESZOTARSKI, Janusz Waclaw (US) | 1987-09-30 | — | — | EP | claimed |
| WO-1987001703-A1 | POTENT, SELECTIVE OPIOID RECEPTOR AGONISTS AND ANTAGONISTS | RZESZOTARSKI JANUSZ WACLAW | 1987-03-26 | — | — | WO | claimed |
| US-4436921-A | CARCINOSTATIC ACTIVITY | TOYAMA CHEMICAL CO., LTD. (JP) | 1984-03-13 | — | — | US | claimed |
| US-4327088-A | ANTIVIRAL AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1982-04-27 | — | — | US | claimed |