⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biphenyl SCHEMBL28291711 | 0.85 | P2RX7 (0.38) | — | |
| SCHEMBL8761111 | 0.79 | — | — | |
| Formic Acid SCHEMBL31384252 | 0.64 | — | — | |
| SCHEMBL1006955 | 0.64 | — | — | |
| SCHEMBL4633794 | 0.64 | — | — | |
| SCHEMBL31384256 | 0.61 | — | — | |
| SCHEMBL6006424 | 0.60 | — | — | |
| SCHEMBL486333 | 0.59 | — | — | |
| SCHEMBL12473381 | 0.58 | — | — | |
| SCHEMBL1231009 | 0.58 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 392 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109810110-B | Compound with 2-aminopyrimidine structure, preparation method and application thereof | 中国科学院上海药物研究所 | 2023-01-24 | — | — | CN | claimed |
| CN-104918939-B | Purine inhibitors of human phosphatidylinositol 3-kinase | 默沙东公司 | 2018-08-28 | — | — | CN | claimed |
| EP-2344456-B1 | NOVEL POTASSIUM CHANNEL BLOCKER | JAPAN TOBACCO INC (JP) | 2018-07-25 | — | — | EP | claimed |
| US-9938281-B2 | Purine inhibitors of human phosphatidylinositol 3-kinase delta | MERCK SHARP & DOHME CORP. (US) | 2018-04-10 | — | — | US | claimed |
| US-9730940-B2 | Purine inhibitors of human phosphatidylinositol 3-kinase delta | MERCK SHARP & DOHME (US) | 2017-08-15 | — | — | US | claimed |
| CN-107011285-A | A kind of preparation method of isradipine impurity III | 重庆康刻尔制药有限公司 | 2017-08-04 | — | — | CN | claimed |
| CN-106967006-A | A kind of preparation method of isradipine impurity II | 重庆康刻尔制药有限公司 | 2017-07-21 | — | — | CN | claimed |
| US-8258138-B2 | Potassium channel blockers | XENTION LIMITED (GB) | 2012-09-04 | — | — | US | claimed |
| EP-1730152-B1 | TETRAHYDROQUINOLINE DERIVATIVES AND A PROCESS FOR PREPARING THE SAME | MITSUBISHI TANABE PHARMA CORP (JP) | 2012-05-02 | — | — | EP | claimed |
| US-20110039828-A1 | TETRAHYDROQUINOLINE DERIVATIVES AND A PROCESS FOR PREPARING THE SAME | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2011-02-17 | — | — | US | claimed |
| EP-1732924-A2 | TETRAHYDRONAPHTHYRIDINE DERIVATIVES AS CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS | TANABE SEIYAKU CO., LTD. (JP) | 2006-12-20 | — | — | EP | claimed |
| WO-2005095395-A2 | TETRAHYDRONAPHTHYRIDINE DERIVATIVES AS CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS | TANABE SEIYAKU CO., LTD. (JP) | 2005-10-13 | — | — | WO | claimed |
| US-6908926-B1 | Substituted imidazoles, their preparation and use | NOVO NORDISK A/S (DK) | 2005-06-21 | — | — | US | claimed |
| US-6294536-B1 | CONTROL OF PROTOZOA AND REDUCTION IN THE INCIDENCE OF ASSOCIATED DISEASES AND DEATH AND CONSEQUENT IMPROVEMENT IN RETARDED GROWTH AND GENERAL CONDITION AND PREVENTING DECREASE GROWTH AND GENERAL CONDITION | TAKEDA SCHERING-PLOUGH ANIMAL HEALTH K.K. (JP) | 2001-09-25 | — | — | US | claimed |
| EP-0851861-A1 | SUBSTITUTED 1-AMINO-3-PHENYLURACIL DERIVATIVES, THEIR PREPARATION AND THEIR USE AS HERBICIDES | BAYER AG (DE) | 1998-07-08 | — | — | EP | claimed |
| EP-0590415-B1 | 1,2,4-Oxadiazole derivatives for controlling endoparasites | BAYER AG (DE) | 1997-06-04 | — | — | EP | claimed |
| WO-1997009319-A1 | SUBSTITUTED 1-AMINO-3-PHENYLURACIL DERIVATIVES, THEIR PREPARATION AND THEIR USE AS HERBICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1997-03-13 | — | — | WO | claimed |
| US-5428047-A | Nematocides | BAYER AKTIENGESELLSCHAFT (DE) | 1995-06-27 | — | — | US | claimed |
| EP-0590415-A2 | 1,2,4-Oxadiazole derivatives for controlling endoparasites | BAYER AG (DE) | 1994-04-06 | — | — | EP | claimed |
| US-4005081-A | 3-Heterothiomethyl-7α-methoxy-7β-tetrazolylmethylthioacetamido-3-cephem derivatives | E. R. SQUIBB & SONS, INC. (US) | 1977-01-25 | — | — | US | claimed |