Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OGA | O60502 | 7/20 | 0.40 |
| ▸ | RAB9A | P51151 | 8/20 | 0.40 |
| ▸ | NPC1 | O15118 | 7/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19454673 | 0.81 | HRH3 (0.44) | RAB9ANPC1MAPTHRH3ALDH1A1 | |
| SCHEMBL21588424 | 0.78 | NPC1 (0.54) | RAB9ANPC1MAPTHRH3ALDH1A1 | |
| SCHEMBL19449840 | 0.78 | SCN4A (0.46) | RAB9ANPC1MAPTHRH3ALDH1A1 | |
| SCHEMBL19435033 | 0.78 | RAB9A (0.46) | RAB9ANPC1MAPTALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL29504646 | 0.77 | SCN4A (0.45) | RAB9ANPC1MAPTHRH3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL19435027 | 0.77 | SCN4A (0.45) | RAB9ANPC1MAPTHRH3ALDH1A1 | |
| SCHEMBL3469499 | 0.74 | RAB9A (0.55) | OGARAB9ANPC1MAPTALDH1A1 | |
| SCHEMBL19438974 | 0.74 | RAB9A (0.40) | OGARAB9ANPC1HRH3ALDH1A1 | |
| SCHEMBL15333499 | 0.73 | HRH3 (0.44) | OGARAB9AMAPTHRH3ALDH1A1 | |
| SCHEMBL19434953 | 0.73 | CNR2 (0.50) | HRH3CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3440087-A1 | THIAZOLOPYRIDINE DERIVATIVES AS GPR119 AGONISTS | MANKIND PHARMA LTD (IN) | 2019-02-13 | — | — | EP | disclosed |
| WO-2017175068-A1 | THIAZOLOPYRIDINE DERIVATIVES AS GPR119 AGONISTS | MANKIND PHARMA LTD. (IN) | 2017-10-12 | — | — | WO | disclosed |