Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.41 |
| ▸ | NME4 | O00746 | 1/20 | 0.40 |
| ▸ | GCDH | Q92947 | 1/20 | 0.40 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19442541 | 0.92 | KMT2A (0.43) | KMT2AHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL19440791 | 0.88 | NPC1 (0.52) | KMT2AHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL19442564 | 0.88 | HDAC1 (0.43) | HDAC1HDAC8HDAC6 | |
| SCHEMBL19440883 | 0.83 | ALDH1A1 (0.53) | KMT2AMEN1NPC1ALDH1A1MAPT | |
| SCHEMBL19440796 | 0.83 | NPC1 (0.43) | KMT2AHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL19442479 | 0.83 | HSP90AA1 (0.55) | KMT2AHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL19440797 | 0.83 | NPC1 (0.42) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL19440820 | 0.83 | EPHX2 (0.57) | KMT2AHDAC3HDAC1POLBMEN1 | |
| SCHEMBL19442527 | 0.82 | KMT2A (0.44) | KMT2AHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL17511304 | 0.81 | HDAC3 (0.47) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9783510-B2 | Small molecule mediated transcriptional induction of E-cadherin | VANDERBILT UNIVERSITY (US) | 2017-10-10 | — | — | US | disclosed |
| US-9783510-B2 | Small molecule mediated transcriptional induction of E-cadherin | VANDERBILT UNIVERSITY (US) | 2017-10-10 | — | — | US | disclosed |