Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 3/20 | 0.57 |
| ▸ | JAK3 | P52333 | 9/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | CTSC | P53634 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SIK1 | P57059 | 1/20 | 0.42 |
| ▸ | MELK | Q14680 | 1/20 | 0.42 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.42 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 4/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | TTK | P33981 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | TXK | P42681 | 1/20 | 0.42 |
| ▸ | BLK | P51451 | 1/20 | 0.42 |
| ▸ | ITK | Q08881 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21081534 | 0.94 | BTK (0.65) | BTKJAK3FGFR1CTSCCYP3A4 | |
| SCHEMBL17857017 | 0.90 | BTK (0.70) | BTKJAK3FGFR1CTSCEGFR | |
| SCHEMBL21081536 | 0.89 | BTK (0.57) | BTKJAK3FGFR1CTSCCYP3A4 | |
| SCHEMBL21081507 | 0.89 | BTK (0.58) | BTKJAK3FGFR1CTSCCYP3A4 | |
| SCHEMBL19441964 | 0.88 | BTK (0.57) | BTKJAK3FGFR1EGFR | |
| SCHEMBL17857020 | 0.87 | BTK (0.53) | BTKJAK3FGFR1CYP3A4CYP2C9 | |
| SCHEMBL19441912 | 0.86 | BTK (0.53) | BTKJAK3FGFR1CTSCCYP3A4 | |
| SCHEMBL17837342 | 0.84 | BTK (0.81) | BTKJAK3FGFR1CTSCEGFR | |
| SCHEMBL17857022 | 0.82 | BTK (0.65) | BTKJAK3CYP3A4CYP2C9FGFR3 | |
| SCHEMBL17857021 | 0.81 | BTK (0.66) | BTKJAK3CTSCCYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9783504-B2 | Kinase inhibitors for the treatment of disease | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-10-10 | — | — | US | disclosed |