Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 3/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.44 |
| ▸ | EGFR | P00533 | 10/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | GAK | O14976 | 1/20 | 0.41 |
| ▸ | FES | P07332 | 1/20 | 0.41 |
| ▸ | FER | P16591 | 1/20 | 0.41 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.41 |
| ▸ | TEC | P42680 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.41 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.41 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21081534 | 0.94 | BTK (0.65) | BTKFGFR1EGFRJAK3 | |
| SCHEMBL17857049 | 0.90 | BTK (0.70) | BTKFGFR1ALKEGFRJAK3 | |
| SCHEMBL21081507 | 0.89 | BTK (0.58) | BTKFGFR1ALKEGFRJAK3 | |
| SCHEMBL21081536 | 0.88 | BTK (0.57) | BTKFGFR1EGFRJAK3 | |
| SCHEMBL19441963 | 0.88 | BTK (0.57) | BTKFGFR1EGFRJAK3 | |
| SCHEMBL19441912 | 0.85 | BTK (0.53) | BTKFGFR1ALKEGFRJAK3 | |
| SCHEMBL17837342 | 0.84 | BTK (0.81) | BTKFGFR1EGFRJAK3 | |
| SCHEMBL17857046 | 0.83 | BTK (0.70) | BTKFGFR1EGFRJAK3 | |
| SCHEMBL17857045 | 0.82 | BTK (0.71) | BTKFGFR1EGFRJAK3 | |
| SCHEMBL17857021 | 0.81 | BTK (0.66) | BTKEGFRJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9783504-B2 | Kinase inhibitors for the treatment of disease | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-10-10 | — | — | US | disclosed |