Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.73 |
| ▸ | GAA | P10253 | 3/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | GLA | P06280 | 1/20 | 0.63 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.60 |
| ▸ | HTT | P42858 | 3/20 | 0.60 |
| ▸ | RAF1 | P04049 | 2/20 | 0.60 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.60 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | EGFR | P00533 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10237224 | 0.97 | MAPT (0.68) | MAPTALDH1A1GAAKDM4EMAPK1 | |
| SCHEMBL29881929 | 0.84 | MAPT (1.00) | MAPTALDH1A1GAAKDM4EMAPK1 | |
| SCHEMBL12375203 | 0.81 | MAPT (0.94) | MAPTALDH1A1GAAKDM4EMAPK1 | |
| SCHEMBL10343492 | 0.81 | IRAK4 (0.77) | MAPTALDH1A1GAAKDM4EMAPK1 | |
| SCHEMBL10343557 | 0.81 | IRAK4 (0.77) | MAPTALDH1A1GAAKDM4EMAPK1 | |
| SCHEMBL10343576 | 0.81 | IRAK4 (0.77) | MAPTALDH1A1GAAKDM4EMAPK1 | |
| SCHEMBL13164880 | 0.80 | IRAK4 (0.76) | MAPTALDH1A1GAAKDM4EMAPK1 | |
| SCHEMBL10343525 | 0.79 | LIMK1 (0.66) | MAPTALDH1A1GAAKDM4EMAPK1 | |
| SCHEMBL10343388 | 0.79 | IRAK4 (0.74) | MAPTALDH1A1GAAKDM4EMAPK1 | |
| SCHEMBL5313910 | 0.79 | LMNA (0.63) | MAPTALDH1A1GAAKDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074115-B1 | N3-HETEROARYL SUBSTITUTED TRIAZOLES AND N5-HETEROARYL SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS | RIGEL PHARMACEUTICALS INC (US) | 2018-03-07 | — | — | EP | disclosed |
| EP-2663312-B1 | IRAK INHIBITORS AND USES THEREOF | NIMBUS IRIS INC (US) | 2017-10-11 | — | — | EP | disclosed |