Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ARG1 | P05089 | 2/20 | 0.31 |
| ▸ | ARG2 | P78540 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17549275 | 1.00 | TSHR (0.35) | TSHRLMNAPOLBALDH1A1HRH3 | |
| Hydrochloric Acid SCHEMBL19133670 | 0.99 | TSHR (0.34) | TSHRLMNAPOLBALDH1A1HRH3 | |
| SCHEMBL19719451 | 0.86 | TSHR (0.36) | TSHRLMNAPOLBALDH1A1HRH3 | |
| SCHEMBL19448264 | 0.86 | TSHR (0.36) | TSHRLMNAPOLBALDH1A1HRH3 | |
| SCHEMBL19719415 | 0.86 | TSHR (0.36) | TSHRLMNAPOLBALDH1A1HRH3 | |
| SCHEMBL19448262 | 0.86 | MAPT (0.34) | TSHRLMNAPOLBALDH1A1CYP2D6 | |
| SCHEMBL19448263 | 0.86 | MAPT (0.34) | TSHRLMNAPOLBALDH1A1CYP2D6 | |
| SCHEMBL17549020 | 0.85 | TSHR (0.36) | TSHRLMNAPOLBALDH1A1HRH3 | |
| SCHEMBL17549021 | 0.85 | TSHR (0.36) | TSHRLMNAPOLBALDH1A1HRH3 | |
| SCHEMBL19156490 | 0.85 | TSHR (0.36) | TSHRLMNAPOLBALDH1A1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9844549-B2 | 2-aminothiazole derivative or salt thereof | ASTELLAS PHARMA INC. (JP) | 2017-12-19 | — | — | US | disclosed |
| US-9844549-B2 | 2-aminothiazole derivative or salt thereof | ASTELLAS PHARMA INC. (JP) | 2017-12-19 | — | — | US | disclosed |
| US-20170290824-A1 | 2-AMINOTHIAZOLE DERIVATIVE OR SALT THEREOF | ASTELLAS PHARMA INC. (JP) | 2017-10-12 | — | — | US | disclosed |
| US-20170290824-A1 | 2-AMINOTHIAZOLE DERIVATIVE OR SALT THEREOF | ASTELLAS PHARMA INC. (JP) | 2017-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170290824-A1 | 2-AMINOTHIAZOLE DERIVATIVE OR SALT THEREOF | CHRM3, CHRM2, TRPM2 | TSHR 1687/4885LMNA 4516/4885POLB 4696/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.