Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 19/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 18/20 | 0.44 |
| ▸ | JAK3 | P52333 | 11/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | WEE1 | P30291 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23216 | 0.82 | BCL6 (0.48) | PTK2 | |
| SCHEMBL15221144 | 0.74 | JAK2 (0.46) | JAK2PTK2JAK3 | |
| SCHEMBL20035 | 0.74 | JAK2 (0.51) | JAK2PTK2JAK3WEE1 | |
| SCHEMBL16394337 | 0.74 | FLT3 (0.48) | JAK2PTK2JAK3 | |
| SCHEMBL21072 | 0.74 | JAK2 (0.40) | JAK2PTK2JAK3 | |
| SCHEMBL21018 | 0.73 | NFKB1 (0.51) | JAK2PTK2JAK3 | |
| SCHEMBL15210422 | 0.72 | SYK (0.51) | JAK2PTK2JAK3WEE1 | |
| SCHEMBL19266 | 0.72 | KDR (0.48) | JAK2PTK2JAK3 | |
| SCHEMBL15210382 | 0.72 | JAK2 (0.53) | JAK2PTK2JAK3 | |
| SCHEMBL15221132 | 0.71 | PSEN1 (0.46) | JAK2PTK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609098-A1 | TRIAZOLOPYRAZINE DERIVATIVES | Merck Patent GmbH (DE) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012025186-A1 | TRIAZOLOPYRAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-03-01 | — | — | WO | disclosed |