Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 20/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19454234 | 1.00 | ESR1 (0.61) | ESR1 | |
| SCHEMBL20143132 | 0.93 | ESR1 (0.59) | ESR1 | |
| SCHEMBL20143128 | 0.93 | ESR1 (0.59) | ESR1 | |
| SCHEMBL19439356 | 0.88 | ESR1 (0.61) | ESR1 | |
| SCHEMBL19439359 | 0.88 | ESR1 (0.61) | ESR1 | |
| SCHEMBL19439319 | 0.88 | ESR1 (0.61) | ESR1 | |
| SCHEMBL19565434 | 0.87 | ESR1 (0.47) | ESR1 | |
| SCHEMBL19439349 | 0.83 | ESR1 (0.60) | ESR1 | |
| SCHEMBL19439321 | 0.83 | ESR1 (0.60) | ESR1 | |
| SCHEMBL19454289 | 0.83 | ESR1 (0.60) | ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109219604-B | Tetrahydroisoquinoline estrogen receptor modulators and uses thereof | 豪夫迈·罗氏有限公司 | 2021-09-24 | — | — | CN | claimed |
| EP-3440067-B1 | TETRAHYDROISOQUINOLINE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2021-05-26 | — | — | EP | claimed |
| EP-3440067-B1 | TETRAHYDROISOQUINOLINE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2021-05-26 | — | — | EP | disclosed |
| US-9969732-B2 | Tetrahydroisoquinoline estrogen receptor modulators and uses thereof | GENENTECH, INC. (US) | 2018-05-15 | — | — | US | disclosed |
| US-9969732-B2 | Tetrahydroisoquinoline estrogen receptor modulators and uses thereof | GENENTECH, INC. (US) | 2018-05-15 | — | — | US | disclosed |
| US-9969732-B2 | Tetrahydroisoquinoline estrogen receptor modulators and uses thereof | GENENTECH, INC. (US) | 2018-05-15 | — | — | US | disclosed |
| US-20170320871-A1 | TETRAHYDROISOQUINOLINE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-09 | — | — | US | disclosed |
| US-20170320871-A1 | TETRAHYDROISOQUINOLINE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-09 | — | — | US | disclosed |
| US-20170320871-A1 | TETRAHYDROISOQUINOLINE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-09 | — | — | US | disclosed |
| WO-2017174757-A1 | TETRAHYDROISOQUINOLINE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2017-10-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170320871-A1 | TETRAHYDROISOQUINOLINE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | GPER1, ESR2, ESR1 | ESR1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.