Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 20/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20143132 | 1.00 | ESR1 (0.59) | ESR1 | |
| SCHEMBL19454234 | 0.93 | ESR1 (0.61) | ESR1 | |
| SCHEMBL19454239 | 0.93 | ESR1 (0.61) | ESR1 | |
| SCHEMBL20143121 | 0.83 | ESR1 (0.58) | ESR1 | |
| SCHEMBL20143175 | 0.83 | ESR1 (0.58) | ESR1 | |
| SCHEMBL19454230 | 0.83 | ESR1 (0.65) | ESR1 | |
| SCHEMBL19454227 | 0.83 | ESR1 (0.65) | ESR1 | |
| SCHEMBL19454226 | 0.83 | ESR1 (0.65) | ESR1 | |
| SCHEMBL19565434 | 0.82 | ESR1 (0.47) | ESR1 | |
| SCHEMBL20143157 | 0.82 | ESR1 (0.51) | ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9969732-B2 | Tetrahydroisoquinoline estrogen receptor modulators and uses thereof | GENENTECH, INC. (US) | 2018-05-15 | — | — | US | disclosed |