Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | SMO | Q99835 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19434851 | 0.91 | CNR2 (0.46) | CNR2EPHX2GPR119CYP3A4CYP2C19 | |
| SCHEMBL29504481 | 0.91 | CNR2 (0.46) | CNR2EPHX2GPR119CYP3A4CYP2C19 | |
| SCHEMBL29504621 | 0.89 | CNR2 (0.42) | CNR2EPHX2GPR119CYP3A4CYP2C19 | |
| SCHEMBL19435013 | 0.89 | CNR2 (0.42) | CNR2EPHX2GPR119CYP3A4CYP2C19 | |
| SCHEMBL19434948 | 0.87 | GPR119 (0.55) | CNR2EPHX2GPR119CYP3A4CYP2C19 | |
| SCHEMBL19454662 | 0.87 | CNR2 (0.42) | CNR2EPHX2GPR119CYP3A4CYP2C19 | |
| SCHEMBL29504581 | 0.85 | CNR2 (0.41) | CNR2EPHX2GPR119CYP3A4CYP2C19 | |
| SCHEMBL19434768 | 0.85 | GPR119 (0.46) | CNR2EPHX2GPR119CYP3A4CYP2C19 | |
| SCHEMBL19434942 | 0.85 | CNR2 (0.41) | CNR2EPHX2GPR119CYP3A4CYP2C19 | |
| SCHEMBL19434953 | 0.85 | CNR2 (0.50) | CNR2EPHX2GPR119CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017175068-A1 | THIAZOLOPYRIDINE DERIVATIVES AS GPR119 AGONISTS | MANKIND PHARMA LTD. (IN) | 2017-10-12 | — | — | WO | disclosed |