Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 9/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | TLR2 | O60603 | 4/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9137286 | 0.86 | DNM1 (0.60) | DNM1CYP3A4ALDH1A1MEN1KMT2A | |
| SCHEMBL30340413 | 0.85 | CYP3A4 (0.52) | DNM1CYP3A4ALDH1A1MEN1KMT2A | |
| SCHEMBL27733389 | 0.84 | DNM1 (0.40) | DNM1CYP3A4ALDH1A1TSHRTDP1 | |
| SCHEMBL4117174 | 0.83 | DNM1 (0.52) | DNM1CYP3A4ALDH1A1MEN1KMT2A | |
| SCHEMBL24709143 | 0.83 | DNM1 (0.45) | DNM1CYP3A4ALDH1A1MEN1KMT2A | |
| SCHEMBL11721798 | 0.82 | CYP1A2 (0.38) | DNM1CYP3A4ALDH1A1MEN1KMT2A | |
| SCHEMBL23270387 | 0.82 | DNM1 (0.55) | DNM1CYP3A4ALDH1A1MEN1KMT2A | |
| SCHEMBL27887388 | 0.81 | DNM1 (0.48) | DNM1CYP3A4ALDH1A1MEN1KMT2A | |
| SCHEMBL16339184 | 0.80 | DNM1 (0.47) | DNM1TSHR | |
| SCHEMBL4640889 | 0.80 | DNM1 (0.42) | DNM1CYP3A4MEN1KMT2ATLR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3440075-B1 | BENZO[B]FURANS AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2020-01-29 | — | — | EP | disclosed |
| WO-2017174620-A1 | BENZO[B]FURANS AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-10-12 | — | — | WO | disclosed |