Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31511656 | 0.90 | NR1H2 (0.42) | GPR119NR1H2MEN1ALDH1A1MAPT | |
| SCHEMBL20913888 | 0.88 | GPR119 (0.41) | GPR119NR1H2MEN1ALDH1A1MAPT | |
| SCHEMBL31511673 | 0.87 | GPR119 (0.40) | GPR119NR1H2MEN1ALDH1A1MAPT | |
| SCHEMBL29831252 | 0.86 | NR1H2 (0.43) | GPR119NR1H2MEN1ALDH1A1MAPT | |
| SCHEMBL19448428 | 0.86 | NR1H2 (0.43) | GPR119NR1H2MEN1ALDH1A1MAPT | |
| SCHEMBL20913884 | 0.85 | NR1H2 (0.40) | GPR119NR1H2MEN1ALDH1A1MAPT | |
| SCHEMBL31511611 | 0.85 | MEN1 (0.46) | GPR119NR1H2MEN1ALDH1A1MAPT | |
| SCHEMBL28569492 | 0.83 | NR1H2 (0.42) | GPR119NR1H2MEN1ALDH1A1MAPT | |
| SCHEMBL2348311 | 0.83 | NR1H2 (0.49) | GPR119NR1H2MEN1ALDH1A1MAPT | |
| SCHEMBL19456224 | 0.83 | NR1H2 (0.38) | GPR119NR1H2MEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017174620-A1 | BENZO[B]FURANS AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-10-12 | — | — | WO | disclosed |