Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 5/20 | 0.44 |
| ▸ | CDK8 | P49336 | 5/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 2/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 2/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.36 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.35 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.35 |
| ▸ | MYC | P01106 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19478313 | 0.88 | CCNC (0.44) | CCNCCDK8SCN9AGSK3BCDC7 | |
| SCHEMBL19478304 | 0.87 | SCN9A (0.40) | SCN9AXDHSLC22A12GRM2TGFBR1 | |
| SCHEMBL16580114 | 0.87 | GRM2 (0.44) | XDHSLC22A12GRM2TGFBR1MYC | |
| SCHEMBL19478196 | 0.86 | GSK3B (0.41) | CCNCCDK8SCN9AGSK3BCDC7 | |
| SCHEMBL16570944 | 0.86 | SLC22A12 (0.39) | SCN9AXDHSLC22A12GRM2TGFBR1 | |
| SCHEMBL16580108 | 0.86 | SLC22A12 (0.39) | XDHSLC22A12GRM2TGFBR1 | |
| SCHEMBL16580054 | 0.85 | CCNC (0.38) | CCNCCDK8XDHSLC22A12TGFBR1 | |
| SCHEMBL19457991 | 0.85 | SLC22A12 (0.35) | CCNCCDK8SCN9AXDHSLC22A12 | |
| SCHEMBL16580105 | 0.85 | PTGDR2 (0.41) | XDHSLC22A12 | |
| SCHEMBL16580111 | 0.85 | SLC22A12 (0.38) | XDHSLC22A12GRM2IKBKBCHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3044207-B1 | INDOL-CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2017-10-18 | — | — | EP | claimed |
| EP-3044207-B1 | INDOL-CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2017-10-18 | — | — | EP | disclosed |