Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 3/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.34 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19478199 | 0.87 | THRB (0.40) | HPGDXDHSLC22A12EGLN1EGLN2 | |
| SCHEMBL19457992 | 0.86 | CCNC (0.44) | GSK3BCCNCCDK8PDE3BPDE3A | |
| SCHEMBL19478355 | 0.78 | LRRK2 (0.38) | GSK3BBRAFCCNCCDK8HPGD | |
| SCHEMBL19478338 | 0.77 | TRPA1 (0.38) | HPGDEGLN2TRPA1 | |
| SCHEMBL19478361 | 0.74 | APP (0.36) | XDHSLC22A12 | |
| SCHEMBL19478313 | 0.74 | CCNC (0.44) | GSK3BCCNCCDK8PDE3BPDE3A | |
| SCHEMBL16571097 | 0.74 | CCNC (0.46) | CCNCCDK8HPGDPDE3BPDE3A | |
| SCHEMBL19478304 | 0.73 | SCN9A (0.40) | XDHSLC22A12SCN9A | |
| SCHEMBL16580114 | 0.73 | GRM2 (0.44) | HPGDXDHSLC22A12 | |
| SCHEMBL16580054 | 0.73 | CCNC (0.38) | CCNCCDK8XDHSLC22A12GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3044207-B1 | INDOL-CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2017-10-18 | — | — | EP | disclosed |