Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTC | P00480 | 1/20 | 0.44 |
| ▸ | NOS2 | P35228 | 6/20 | 0.43 |
| ▸ | NOS1 | P29475 | 5/20 | 0.43 |
| ▸ | NOS3 | P29474 | 4/20 | 0.43 |
| ▸ | DDAH1 | O94760 | 3/20 | 0.42 |
| ▸ | BHMT | Q93088 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | GSR | P00390 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL16099882 | 1.00 | OTC (0.44) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL16099880 | 1.00 | OTC (0.44) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL4171389 | 0.89 | OTC (0.44) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL15140178 | 0.89 | OTC (0.44) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL16179489 | 0.89 | OTC (0.44) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL16179227 | 0.89 | OTC (0.44) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL27873762 | 0.89 | OTC (0.44) | OTCNOS2NOS1NOS3DDAH1 | |
| L-Citrulline SCHEMBL16098617 | 0.88 | OTC (0.47) | OTCNOS2NOS1NOS3DDAH1 | |
| L-Citrulline SCHEMBL16098618 | 0.88 | OTC (0.47) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL29422943 | 0.88 | OTC (0.47) | OTCNOS2NOS1NOS3DDAH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240226043-A1 | ADMINISTRATION OF R-BETA-HYDROXYBUTYRATE AND RELATED COMPOUNDS IN HUMANS | AXCESS GLOBAL SCIENCES, LLC | 2024-07-11 | — | — | US | disclosed |
| US-11969411-B2 | Administration of berberine metabolites | AXCESS GLOBAL SCIENCES, LLC (US) | 2024-04-30 | — | — | US | disclosed |
| EP-3445355-B1 | BETA-HYDROXYBUTYRATE FOR USE IN NON-THERAPEUTIC METHODS OF CONTROLLING WEIGHT LOSS AND KETOTIS | AXCESS GLOBAL SCIENCES LLC (US) | 2023-11-29 | — | — | EP | disclosed |
| US-20230346723-A1 | ADMINISTRATION OF R-BETA-HYDROXYBUTYRATE AND RELATED COMPOUNDS IN HUMANS | AXCESS GLOBAL SCIENCES, LLC | 2023-11-02 | — | — | US | disclosed |
| WO-2023212319-A1 | ADMINISTRATION OF R-BETA-HYDROXYBUTYRATE SALT BLEND AND RELATED COMPOUNDS IN HUMANS | AXCESS GLOBAL SCIENCES, LLC (US) | 2023-11-02 | — | — | WO | disclosed |
| WO-2023081409-A1 | ADMINISTRATION OF BERBERINE METABOLITES | Keto Patent Group, Inc. (US) | 2023-05-11 | — | — | WO | disclosed |
| US-20220202789-A1 | ADMINISTRATION OF BERBERINE METABOLITES | AXCESS GLOBAL SCIENCES, LLC | 2022-06-30 | — | — | US | disclosed |
| US-20220047578-A1 | ADMINISTRATION OF BERBERINE METABOLITES | AXCESS GLOBAL SCIENCES, LLC | 2022-02-17 | — | — | US | disclosed |
| US-20210393560-A1 | ADMINISTRATION OF R-BETA-HYDROXYBUTYRATE AND RELATED COMPOUNDS IN HUMANS | AXCESS GLOBAL SCIENCES, LLC | 2021-12-23 | — | — | US | disclosed |
| US-11173138-B2 | Administration of butyrate, beta-hydroxybutyrate, and related compounds in humans | Keto Patent Group, Inc. (US) | 2021-11-16 | — | — | US | disclosed |
| EP-3873442-A1 | ADMINISTRATION OF BUTYRATE, BETE-HYDROXYBUTYRATE, CANNABIDIOL, AND RELATED COMPOUNDS IN HUMANS | Keto Patent Group, Inc. (US) | 2021-09-08 | — | — | EP | disclosed |
| US-20200129463-A1 | ADMINISTRATION OF BUTYRATE, BETA-HYDROXYBUTYRATE, CANNABIDIOL, AND RELATED COMPOUNDS IN HUMANS | AXCESS GLOBAL SCIENCES, LLC | 2020-04-30 | — | — | US | disclosed |
| WO-2017184788-A1 | ADMINISTRATION OF BUTYRATE, BETA-HYDROXYBUTYRATE, AND RELATED COMPOUNDS IN HUMANS | Keto Patent Group, Inc. (US) | 2017-10-26 | — | — | WO | disclosed |
| US-20170296501-A1 | ADMINISTRATION OF BUTYRATE, BETA-HYDROXYBUTYRATE, AND RELATED COMPOUNDS IN HUMANS | AXCESS GLOBAL SCIENCES, LLC | 2017-10-19 | — | — | US | disclosed |