Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTC | P00480 | 1/20 | 0.44 |
| ▸ | NOS2 | P35228 | 8/20 | 0.43 |
| ▸ | NOS1 | P29475 | 8/20 | 0.43 |
| ▸ | NOS3 | P29474 | 6/20 | 0.43 |
| ▸ | DDAH1 | O94760 | 3/20 | 0.42 |
| ▸ | BHMT | Q93088 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | GSR | P00390 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL16179489 | 1.00 | OTC (0.44) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL27873762 | 1.00 | OTC (0.44) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL15140178 | 1.00 | OTC (0.44) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL16179227 | 1.00 | OTC (0.44) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL27438301 | 0.97 | OTC (0.43) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL3633342 | 0.96 | OTC (0.42) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL3633339 | 0.96 | OTC (0.42) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL6433292 | 0.96 | OTC (0.42) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL6433284 | 0.96 | OTC (0.42) | OTCNOS2NOS1NOS3DDAH1 | |
| Arginine SCHEMBL8729920 | 0.95 | OTC (0.41) | OTCNOS2NOS1NOS3DDAH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140329914-A1 | Amphiphilic Peptides for Thoracic Air Leakage Occlusion | 3-D Matrix Ltd. (JP) | 2014-11-06 | — | — | US | claimed |
| EP-2750687-A2 | AMPHIPHILIC PEPTIDES FOR THORACIC AIR LEAKAGE OCCLUSION | 3-D Matrix, Ltd. (JP) | 2014-07-09 | — | — | EP | claimed |
| WO-2013030673-A2 | AMPHIPHILIC PEPTIDES FOR THORACIC AIR LEAKAGE OCCLUSION | 3-D MATRIX, LTD. (JP) | 2013-03-07 | — | — | WO | claimed |
| US-11857648-B2 | Dimerization strategies and compounds for molecular imaging and/or radioimmunotherapy | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2024-01-02 | — | — | US | disclosed |
| US-20190134240-A1 | DIMERIZATION STRATEGIES AND COMPOUNDS FOR MOLECULAR IMAGING AND/OR RADIOIMMUNOTHERAPY | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2019-05-09 | — | — | US | disclosed |
| EP-2750687-B1 | AMPHIPHILIC PEPTIDES FOR THORACIC AIR LEAKAGE OCCLUSION | 3-D MATRIX LTD (JP) | 2017-12-06 | — | — | EP | disclosed |
| WO-2017192605-A1 | DIMERIZATION STRATEGIES AND COMPOUNDS FOR MOLECULAR IMAGING AND/OR RADIOIMMUNOTHERAPY | UNIVERSITY OF PITTSBURGH -OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2017-11-09 | — | — | WO | disclosed |
| US-20140329914-A1 | Amphiphilic Peptides for Thoracic Air Leakage Occlusion | 3-D Matrix Ltd. (JP) | 2014-11-06 | — | — | US | disclosed |
| EP-2750687-A2 | AMPHIPHILIC PEPTIDES FOR THORACIC AIR LEAKAGE OCCLUSION | 3-D Matrix, Ltd. (JP) | 2014-07-09 | — | — | EP | disclosed |
| WO-2013030673-A2 | AMPHIPHILIC PEPTIDES FOR THORACIC AIR LEAKAGE OCCLUSION | 3-D MATRIX, LTD. (JP) | 2013-03-07 | — | — | WO | disclosed |
| US-20090047517-A1 | MULTILAYER POLYMER FILMS | THE UNIVERSITY OF MELBOURNE (AU) | 2009-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190134240-A1 | DIMERIZATION STRATEGIES AND COMPOUNDS FOR MOLECULAR IMAGING AND/OR RADIOIMMUNOTHERAPY | PAICS, CD47, BID | OTC 4860/4885NOS2 4185/4885NOS1 4560/4885 |
| US-11857648-B2 | Dimerization strategies and compounds for molecular imaging and/or radioimmunotherapy | PAICS, CD47, BID | OTC 4860/4885NOS2 4185/4885NOS1 4560/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.