Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 18/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22895130 | 0.89 | TGM2 (0.92) | TGM2 | |
| SCHEMBL31033042 | 0.89 | TGM2 (0.92) | TGM2 | |
| SCHEMBL31032928 | 0.84 | TGM2 (1.00) | TGM2 | |
| SCHEMBL22895131 | 0.84 | TGM2 (1.00) | TGM2 | |
| SCHEMBL19463909 | 0.84 | TGM2 (1.00) | TGM2 | |
| SCHEMBL19480342 | 0.84 | TGM2 (1.00) | TGM2 | |
| SCHEMBL22895129 | 0.81 | TGM2 (0.84) | TGM2 | |
| SCHEMBL31033038 | 0.81 | TGM2 (0.84) | TGM2 | |
| SCHEMBL17076473 | 0.81 | TGM2 (1.00) | TGM2KMT2AATM | |
| SCHEMBL19463905 | 0.80 | TGM2 (0.71) | TGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3442533-A1 | TG2 INHIBITOR COMPOUNDS AND USES THEREOF | University Of Ottawa (CA) | 2019-02-20 | — | — | EP | disclosed |
| WO-2017179018-A1 | TG2 INHIBITOR COMPOUNDS AND USES THEREOF | UNIVERSITY OF OTTAWA (CA) | 2017-10-19 | — | — | WO | disclosed |