Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 18/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19465582 | 0.87 | CFTR (0.54) | CFTRKDM4EALDH1A1HPGD | |
| SCHEMBL19465593 | 0.80 | CFTR (0.49) | CFTRKDM4EMEN1ALDH1A1GAA | |
| SCHEMBL18694250 | 0.75 | CFTR (0.72) | CFTR | |
| SCHEMBL18693073 | 0.75 | CFTR (0.75) | CFTR | |
| SCHEMBL18694703 | 0.75 | CFTR (0.75) | CFTR | |
| SCHEMBL18693599 | 0.72 | CFTR (0.63) | CFTR | |
| SCHEMBL18693653 | 0.72 | CFTR (0.87) | CFTR | |
| SCHEMBL18693927 | 0.72 | CFTR (0.68) | CFTR | |
| SCHEMBL18694653 | 0.72 | CFTR (0.65) | CFTR | |
| SCHEMBL19465611 | 0.71 | CFTR (0.61) | CFTRKDM4EMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9796711-B2 | Substituted pyrazolo[3,4-b]pyridin-6-carboxylic acids and method of use | ABBVIE S.Á.R.L. (LU) | 2017-10-24 | — | — | US | disclosed |