Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 18/20 | 0.54 |
| ▸ | RPA1 | P27694 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19465571 | 0.87 | CFTR (0.52) | CFTRKDM4EALDH1A1HPGD | |
| SCHEMBL18717671 | 0.80 | CFTR (0.64) | CFTR | |
| SCHEMBL18692236 | 0.80 | CFTR (0.64) | CFTR | |
| SCHEMBL19465609 | 0.78 | CFTR (0.42) | CFTRKDM4E | |
| SCHEMBL18693922 | 0.77 | CFTR (0.62) | CFTRALDH1A1 | |
| SCHEMBL18694011 | 0.76 | CFTR (0.60) | CFTR | |
| SCHEMBL19465578 | 0.76 | KDM4E (0.60) | CFTRKDM4EALDH1A1HPGD | |
| SCHEMBL18694727 | 0.75 | CFTR (0.59) | CFTR | |
| SCHEMBL18693073 | 0.75 | CFTR (0.75) | CFTR | |
| SCHEMBL18694703 | 0.75 | CFTR (0.75) | CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9796711-B2 | Substituted pyrazolo[3,4-b]pyridin-6-carboxylic acids and method of use | ABBVIE S.Á.R.L. (LU) | 2017-10-24 | — | — | US | disclosed |