Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 2/20 | 0.42 |
| ▸ | PDE7A | Q13946 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PDE9A | O76083 | 7/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 1/20 | 0.35 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19465609 | 0.79 | CFTR (0.42) | CFTRKMT2AKDM4EGLAHTT | |
| SCHEMBL18694283 | 0.78 | CFTR (0.46) | CFTRKDM4ENR3C1MAPK13MAPK12 | |
| SCHEMBL18694123 | 0.75 | CFTR (0.48) | CFTRPDE7AKDM4EPDE9ANR3C1 | |
| SCHEMBL18694178 | 0.75 | CFTR (0.49) | CFTRKDM4ENR3C1 | |
| SCHEMBL18694643 | 0.73 | CFTR (0.47) | CFTRKDM4ENR3C1MAPK13MAPK12 | |
| SCHEMBL18694394 | 0.73 | CFTR (0.53) | CFTRKDM4ENR3C1 | |
| SCHEMBL18692209 | 0.72 | CFTR (0.52) | CFTRNR3C1 | |
| SCHEMBL18693388 | 0.72 | CFTR (0.54) | CFTRPDE7AKDM4ESMN1; SMN2NR3C1 | |
| SCHEMBL18693756 | 0.71 | CFTR (0.49) | CFTRPDE7AKDM4ENR3C1 | |
| SCHEMBL18693112 | 0.71 | CFTR (0.51) | CFTRNR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9796711-B2 | Substituted pyrazolo[3,4-b]pyridin-6-carboxylic acids and method of use | ABBVIE S.Á.R.L. (LU) | 2017-10-24 | — | — | US | disclosed |