Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 7/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | LDHA | P00338 | 1/20 | 0.34 |
| ▸ | PDE9A | O76083 | 1/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.34 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19465613 | 0.79 | CFTR (0.42) | CFTRKDM4EGLAHTTKMT2A | |
| SCHEMBL19465582 | 0.78 | CFTR (0.54) | CFTRKDM4E | |
| SCHEMBL28495364 | 0.77 | CFTR (0.47) | CFTRKDM4EKMOLDHA | |
| SCHEMBL18692896 | 0.74 | CFTR (0.51) | CFTRKDM4EGLAHTTKMT2A | |
| SCHEMBL925299 | 0.72 | SMN1; SMN2 (0.44) | CFTRKDM4EGLAHTTKMT2A | |
| SCHEMBL18693139 | 0.71 | CFTR (0.52) | CFTR | |
| SCHEMBL19465571 | 0.71 | CFTR (0.52) | CFTRKDM4EKMT2A | |
| SCHEMBL1711661 | 0.69 | KDM4E (0.51) | KDM4EGLAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL18732871 | 0.69 | CFTR (0.52) | CFTR | |
| SCHEMBL18692687 | 0.68 | CFTR (0.57) | CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9796711-B2 | Substituted pyrazolo[3,4-b]pyridin-6-carboxylic acids and method of use | ABBVIE S.Á.R.L. (LU) | 2017-10-24 | — | — | US | disclosed |