Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 19/20 | 0.71 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2949508 | 0.86 | FYN (0.79) | FYNMKNK1 | |
| SCHEMBL13234627 | 0.83 | FYN (1.00) | FYN | |
| SCHEMBL30521869 | 0.83 | FYN (1.00) | FYN | |
| SCHEMBL13234744 | 0.82 | FYN (0.72) | FYN | |
| SCHEMBL1054937 | 0.82 | FYN (1.00) | FYNMKNK1 | |
| SCHEMBL19467236 | 0.82 | FYN (0.67) | FYNMKNK1 | |
| SCHEMBL19467037 | 0.81 | FYN (0.58) | FYNMKNK1 | |
| SCHEMBL15254508 | 0.81 | FYN (0.54) | FYNMKNK1 | |
| SCHEMBL19467113 | 0.79 | FYN (0.72) | FYNMKNK1 | |
| SCHEMBL19467257 | 0.79 | FYN (0.72) | FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2822559-B1 | IMIDAZO[1,2-B]PYRIDAZINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND USES THEREOF | LEXICON PHARMACEUTICALS INC (US) | 2018-05-02 | — | — | EP | disclosed |
| EP-2822555-B1 | INHIBITION OF ADAPTOR ASSOCIATED KINASE 1 FOR THE TREATMENT OF PAIN | LEXICON PHARMACEUTICALS INC (US) | 2017-11-08 | — | — | EP | disclosed |
| EP-3235499-A2 | INHIBITION OF ADAPTOR ASSOCIATED KINASE 1 FOR THE TREATMENT OF PAIN | Lexicon Pharmaceuticals, Inc. (US) | 2017-10-25 | — | — | EP | disclosed |