Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 15/20 | 0.67 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.58 |
| ▸ | PIM1 | P11309 | 4/20 | 0.50 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19467257 | 0.87 | FYN (0.72) | FYNPIM1PIM2 | |
| SCHEMBL19467296 | 0.84 | FYN (0.72) | FYNPIM1PIM2 | |
| SCHEMBL15254508 | 0.83 | FYN (0.54) | FYNMKNK1PIM1 | |
| SCHEMBL19467037 | 0.82 | FYN (0.58) | FYNMKNK1PIM1 | |
| SCHEMBL19466926 | 0.82 | MKNK1 (0.50) | FYNMKNK1PIM1PIM2 | |
| SCHEMBL19467113 | 0.82 | FYN (0.72) | FYNMKNK1PIM1 | |
| SCHEMBL19467008 | 0.82 | FYN (0.71) | FYNMKNK1 | |
| SCHEMBL2948202 | 0.81 | FYN (0.74) | FYNMKNK1PIM1PIM2 | |
| SCHEMBL19467039 | 0.81 | FYN (0.52) | FYNMKNK1 | |
| SCHEMBL2949038 | 0.81 | FYN (1.00) | FYNMKNK1PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2822559-B1 | IMIDAZO[1,2-B]PYRIDAZINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND USES THEREOF | LEXICON PHARMACEUTICALS INC (US) | 2018-05-02 | — | — | EP | disclosed |
| EP-2822555-B1 | INHIBITION OF ADAPTOR ASSOCIATED KINASE 1 FOR THE TREATMENT OF PAIN | LEXICON PHARMACEUTICALS INC (US) | 2017-11-08 | — | — | EP | disclosed |
| EP-3235499-A2 | INHIBITION OF ADAPTOR ASSOCIATED KINASE 1 FOR THE TREATMENT OF PAIN | Lexicon Pharmaceuticals, Inc. (US) | 2017-10-25 | — | — | EP | disclosed |