Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.53 |
| ▸ | FYN | P06241 | 12/20 | 0.53 |
| ▸ | IKBKB | O14920 | 1/20 | 0.52 |
| ▸ | MKNK1 | Q9BUB5 | 6/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.51 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.51 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19467093 | 0.88 | FYN (0.55) | PIM1FYNMKNK1NTRK1NTRK3 | |
| SCHEMBL15254721 | 0.85 | PIM1 (0.62) | PIM1FYNMKNK1NTRK1NTRK3 | |
| SCHEMBL19467085 | 0.84 | FYN (0.72) | PIM1FYNMKNK1 | |
| SCHEMBL19467262 | 0.84 | FYN (0.57) | PIM1FYNMKNK1 | |
| SCHEMBL20119954 | 0.84 | FYN (0.69) | PIM1FYNMKNK1NTRK1NTRK3 | |
| SCHEMBL19466896 | 0.83 | FYN (0.54) | PIM1FYNIKBKBMKNK1NTRK1 | |
| SCHEMBL15254925 | 0.83 | FYN (0.59) | PIM1FYNMKNK1 | |
| SCHEMBL15254347 | 0.82 | FYN (0.62) | PIM1FYNMKNK1 | |
| SCHEMBL15254410 | 0.82 | FYN (0.54) | FYNMKNK1 | |
| SCHEMBL19466910 | 0.81 | FYN (0.55) | PIM1FYNMKNK1NTRK1NTRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2822559-B1 | IMIDAZO[1,2-B]PYRIDAZINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND USES THEREOF | LEXICON PHARMACEUTICALS INC (US) | 2018-05-02 | — | — | EP | disclosed |
| EP-2822555-B1 | INHIBITION OF ADAPTOR ASSOCIATED KINASE 1 FOR THE TREATMENT OF PAIN | LEXICON PHARMACEUTICALS INC (US) | 2017-11-08 | — | — | EP | disclosed |
| EP-3235499-A2 | INHIBITION OF ADAPTOR ASSOCIATED KINASE 1 FOR THE TREATMENT OF PAIN | Lexicon Pharmaceuticals, Inc. (US) | 2017-10-25 | — | — | EP | disclosed |