Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 17/20 | 0.69 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.69 |
| ▸ | PIM1 | P11309 | 1/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.50 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.50 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19467085 | 0.85 | FYN (0.72) | FYNMKNK1PIM1 | |
| SCHEMBL16331413 | 0.84 | FYN (0.66) | FYNMKNK1PIM1 | |
| SCHEMBL19466896 | 0.84 | FYN (0.54) | FYNMKNK1PIM1NTRK1NTRK3 | |
| SCHEMBL19467151 | 0.84 | PIM1 (0.53) | FYNMKNK1PIM1NTRK1NTRK3 | |
| SCHEMBL20119701 | 0.83 | FYN (0.76) | FYNMKNK1 | |
| SCHEMBL16009618 | 0.83 | FYN (0.76) | FYNMKNK1PIM1 | |
| SCHEMBL15254347 | 0.83 | FYN (0.62) | FYNMKNK1PIM1 | |
| SCHEMBL19466910 | 0.82 | FYN (0.55) | FYNMKNK1PIM1NTRK1NTRK3 | |
| SCHEMBL15254988 | 0.82 | FYN (0.76) | FYNMKNK1PIM1 | |
| SCHEMBL19467093 | 0.82 | FYN (0.55) | FYNMKNK1PIM1NTRK1NTRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2822559-B1 | IMIDAZO[1,2-B]PYRIDAZINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND USES THEREOF | LEXICON PHARMACEUTICALS INC (US) | 2018-05-02 | — | — | EP | disclosed |